1,067 research outputs found
Cosmology with two compactification scales
We consider a (4+d)-dimensional spacetime broken up into a (4-n)-dimensional
Minkowski spacetime (where n goes from 1 to 3) and a compact (n+d)-dimensional
manifold. At the present time the n compactification radii are of the order of
the Universe size, while the other d compactification radii are of the order of
the Planck length.Comment: 16 pages, Latex2e, 7 figure
Integrable Multicomponent Perfect Fluid Multidimensional Cosmology II: Scalar Fields
We consider anisotropic cosmological models with an universe of dimension 4
or more, factorized into n>1 Ricci-flat spaces, containing an m-component
perfect fluid of m non-interacting homogeneous minimally coupled scalar fields
under special conditions. We describe the dynamics of the universe: It has a
Kasner-like behaviour near the singularity and isotropizes during the expansion
to infinity.
Some of the considered models are integrable, and classical as well as
quantum solutions are found. Some solutions produce inflation from "nothing".
There exist classical asymptotically anti-de Sitter wormholes, and quantum
wormholes with discrete spectrum.Comment: 28 pages, LaTeX, subm. to Gen. Rel. Gra
Cosmological solutions in multidimensional model with multiple exponential potential
A family of cosmological solutions with Ricci-flat spaces in the
theory with several scalar fields and multiple exponential potential is
obtained when coupling vectors in exponents obey certain relations. Two
subclasses of solutions with power-law and exponential behaviour of scale
factors are singled out. It is proved that power-law solutions may take place
only when coupling vectors are linearly independent and exponential dependence
occurs for linearly dependent set of coupling vectors. A subfamily of solutions
with accelerated expansion is singled out. A generalized isotropization
behaviours of certain classes of general solutions are found. In quantum case
exact solutions to Wheeler-DeWitt equation are obtained and special "ground
state" wave functions are considered.Comment: 22 pages, 1 figur
Einstein and Brans-Dicke frames in multidimensional cosmology
Inhomogeneous multidimensional cosmological models with a higher dimensional
space-time manifold M= M_0 x M_1 ...x M_n are investigated under dimensional
reduction to a D_0-dimensional effective non-minimally coupled sigma-model
which generalizes the familiar Brans-Dicke model.
It is argued that the Einstein frame should be considered as the physical
one. The general prescription for the Einstein frame reformulation of known
solutions in the Brans-Dicke frame is given. As an example, the reformulation
is demonstrated explicitly for the generalized Kasner solutions where it is
shown that in the Einstein frame there are no solutions with inflation of the
external space.Comment: 27 pages, Revte
Quantum Tests of the Foundations of General Relativity
The role of the equivalence principle in the context of non-relativistic
quantum mechanics and matter wave interferometry, especially atom beam
interferometry, will be discussed. A generalised form of the weak equivalence
principle which is capable of covering quantum phenomena too, will be proposed.
It is shown that this generalised equivalence principle is valid for matter
wave interferometry and for the dynamics of expectation values. In addition,
the use of this equivalence principle makes it possible to determine the
structure of the interaction of quantum systems with gravitational and inertial
fields. It is also shown that the path of the mean value of the position
operator in the case of gravitational interaction does fulfill this generalised
equivalence principle.Comment: Classical and Quantum Gravity 15, 13 (1998
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Second Primary Malignant Neoplasms and Survival in Adolescent and Young Adult Cancer Survivors.
Importance: Although the increased incidence of second primary malignant neoplasms (SPMs) is a well-known late effect after cancer, few studies have compared survival after an SPM to survival of the same cancer occurring as first primary malignant neoplasm (PM) by age.
Objective: To assess the survival impact of SPMs in adolescents and young adults (AYAs) (15-39 years) compared with that of pediatric (\u3c15 \u3eyears) and older adult (≥40 years) patients with the same SPMs.
Design, Setting, and Participants: This was a population-based, retrospective cohort study of patients with cancer in 13 Surveillance, Epidemiology and End Results regions in the United States diagnosed from 1992 to 2008 and followed through 2013. Data analysis was performed between June 2016 and January 2017.
Main Outcomes and Measures: Five-year relative survival was calculated overall and for each cancer occurring as a PM or SPM by age at diagnosis. The impact of SPM status on cancer-specific death was examined using multivariable Cox proportional hazards regression.
Results: A total of 15 954 pediatric, 125 750 AYAs, and 878 370 older adult patients diagnosed as having 14 cancers occurring as a PM or SPM were included. Overall, 5-year survival after an SPM was 33.1% lower for children, 20.2% lower for AYAs, and 8.3% lower for older adults compared with a PM at the same age. For the most common SPMs in AYAs, the absolute difference in 5-year survival was 42% lower for secondary non-Hodgkin lymphoma, 19% for secondary breast carcinoma, 15% for secondary thyroid carcinoma, and 13% for secondary soft-tissue sarcoma. Survival by SPM status was significantly worse in younger vs older patients for thyroid, Hodgkin lymphoma, non-Hodgkin lymphoma, acute myeloid leukemia, soft-tissue sarcoma, and central nervous system cancer. Adolescents and young adults with secondary Hodgkin lymphoma (hazard ratio [95% CI], 3.5 [1.7-7.1]); soft-tissue sarcoma (2.8 [2.1-3.9]); breast carcinoma (2.1 [1.8-2.4]); acute myeloid leukemia (1.9 [1.5-2.4]); and central nervous system cancer (1.8 [1.2-2.8]) experienced worse survival compared with AYAs with the same PMs.
Conclusion and Relevance: The adverse impact of SPMs on survival is substantial for AYAs and may partially explain the relative lack of survival improvement in AYAs compared with other age groups. The impact of a particular SPM diagnosis on survival may inform age-specific prevention, screening, treatment, and survivorship recommendations
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